研究简介
长期从事以大数据解析为主导的基础与临床相结合的多学科交叉研究工作，共发表SCI论文50 余篇。其中，其中（共同）第一和通讯作者论文 20 篇，包含Cell (2篇)、Nature、Nature Methods、Nature Review Genetics、Nature Communications等。研究成果入选“中国生命科学十大进展”及“中国生物信息学十大进展”。主持国家自然科学基金和广东省科学基金等项目。研究领域：1.单细胞及时空多组学数据解码与复杂调控网络研究。2.抗肿瘤免疫治疗的多重免疫调控机制及早期肺癌演进规律研究。3.人工智能算法的开发及其在疾病模型中的应用。
荣誉奖励
“国家重大人才项目青年拔尖人才”、“广东省杰出青年科学基金获得者
代表性成果
1. Xianfa Yang^; Bingbing Xie^; Penglei Shen^; Yingying Chen^; Chunjie Li; Fengxiang Tan; Yumeng Yang; Yun Yang; Rui Song; Panpan Mi; Zhiwen Liu; Mingzhu Wen; Patrick P. L. Tam; Shengbao Suo#;Naihe Jing#.2026.Integrated multi-omic atlas reveals the hierarchy of spatiotemporal regulatory networks of mouse gastrulation. Nature Communications. 17:1572.
2. Yanping Lu^; Yuyan Wang^; Meng Xu; Bingbing Xie; Yumeng Yang; Haodong Xu#; Shengbao Suo#. 2026. Assessment of computational methods in predicting TCR–epitope binding recognition. Nature Methods. 23:248-259.
3. Xinqing Lin^; Chunjie Li^; Jiaxi Deng^; Ying Wu; Bingbing Xie; Jingyi Bao; Wenwei Mo; Changhao Zhong; Haiyi Deng; Qingjun Pan; Yuan Qiu; Yuwen He; Shiyue Li; Jia Li; Shengbao Suo#; Chengzhi Zhou#. 2025. Uncovering the immune mechanisms underlying the emergence of immunotherapy-induced pneumonitis in lung cancer patients. Nature Communications. 16:11645.
4. Jincan Ke^;Jian Xu; Jia Liu; Yumeng Yang; Chenkai Guo; Bingbing Xie; Guizhong Cui; Guangdun Peng#; Shengbao Suo#. 2025. High-resolution mapping of single cells in spatial context. Nature Communications. 16:6533.
5. Shengbao Suo#. 2024. Endogenous retroviruses:unveiling new targets for cancer immunotherapy. Nature Reviews Genetics.25(12):827.
6. Fangfang Qu^; Wenjia Li^; Jian Xu^; Ruifang Zhang; Jincan Ke; Xiaodie Ren; Xiaogao Meng; Lexin Qin; Jingna Zhang; Fangru Lu; Xin Zhou; Xi Luo; Zhen Zhang; Minhan Wang; Guangming Wu; Duanqing Pei; Jiekai Chen; Guizhong Cui#; Shengbao Suo#; Guangdun Peng#.2023.Three-dimensional molecular architecture of mouse organogenesis.Nature Communications.14(1):4599.
7. Adrienne M. Luoma^; Shengbao Suo^#; Yifan Wang; Lauren Gunasti; Caroline B.M. Porter; Nancy Nabilsi; Jenny Tadros; Andrew P. Ferretti; Sida Liao; Cagan Gurer; Yu-Hui Chen; Shana Criscitiello; Cora A. Ricker; Danielle Dionne; Orit Rozenblatt-Rosen; Ravindra Uppaluri; Robert I. Haddad; Orr Ashenberg; Aviv Regev; Eliezer M. Van Allen; Gavin MacBeath; Jonathan D. Schoenfeld#; Kai W. Wucherpfennig#.2022.Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy.Cell.185(16):2918-2935.
8. Adrienne M. Luoma^; Shengbao Suo^; Hannah L. Williams; Tatyana Sharova; Keri Sullivan; Michael Manos; Peter Bowling; F. Stephen Hodi; Osama Rahma; Ryan J. Sullivan; Genevieve M. Boland; Jonathan A. Nowak; Stephanie K. Dougan; Michael Dougan#; Guo-Cheng Yuan; Kai W. Wucherpfennig#.2020.Molecular pathways of colon inflammation induced by cancer immunotherapy.Cell. 182(3):655-671.
9. Guangdun Peng^#; Shengbao Suo^; Guizhong Cui^; Fang Yu^; Ran Wang; Jun Chen; Shirui Chen; Zhiwen Liu; Guoyu Chen; Yun Qian; Patrick P.L.Tam; Jing-Dong J.Han#; Naihe Jing#.2019.Molecular architecture of lineage allocation and tissue organization in early mouse embryo.Nature.572(7770):528-532.
10. Shengbao Suo; Qian Zhu; Assieh Saadatpour; Lijiang Fei; Guoji Guo; Guo-Cheng Yuan#.2018.Revealing the critical regulators of cell identity in the mouse cell atlas.Cell Reports. 6(25):1436-1445.
