研究简介
专注于宿主–病原体相互作用及新发人畜共患病的研究。团队通过比较基因组学和免疫学研究分析了野生动物宿主的病毒抗性和耐受机制。并致力于将这些基础研究成果转化为抗病毒和抗炎治疗策略。该研究小组还专注于流行病的预防和控制，开发用于应对未来的流行病的工具、试剂和现场快速诊断技术。
作为研究团队的负责人，Aaron Irving博士获得了中国国家自然科学基金“外国杰出青年研究基金”（RFIS-II）的资助，主持了多项省级重点科研项目，并先后入选多个人才计划。他的研究成果发表在 Nature、Cell、Nature Microbiology、Immunity、Cell Host & Microbe、PNAS等国际顶级学术期刊，其中两篇论文被列为ESI高被引论文。
荣誉奖励
1. 2023年，获国家自然科学基金“外国青年科学家研究基金“（RFIS-II）
2. 2021年，入选浙江省海外高层次人才引进计划青年人才项目
代表性成果
1. Ariadna E. Morales; Yue Dong; Thomas Brown; Kaushal Baid; Dimitrios - Georgios Kontopoulos; Victoria Gonzalez; Zixia Huang; Alexis-Walid Ahmed; Arkadeb Bhuinya; Leon Hilgers; Sylke Winkler; Graham Hughes; Xiaomeng Li; Ping Lu; Yixin Yang; Bogdan M. Kirilenko; Paolo Devanna; Tanya M. Lama; Yomiran Nissan; Martin Pippel; Liliana M. Dávalos; Sonja C. Vernes; Sebastien J. Puechmaille; Stephen J. Rossiter; Yossi Yovel; Joseph B. Prescott; Andreas Kurth; David A. Ray; Burton K. Lim; Eugene Myers; Emma C. Teeling; Arinjay Banerjee; Aaron T. Irving*; Michael Hiller*. 2025. Bat genomes illuminate adaptations to viral tolerance and disease resistance. Nature. 638, 449–458.
2. Mak, Nelly S. C.; Liu, Jingyan; Zhang, Dan; Taylor, Jordan; Li, Xiaomeng; Rahman, Kazi; Chen, Feiyu; Datta, Siddhartha A. K.; Lai, Kin Kui; Shi, Zhengli; Temperton, Nigel; Irving, Aaron T*.; Compton, Alex A*.; Sloan, Richard D.*. 2025. Alternative splicing expands the antiviral IFITM repertoire in Chinese rufous horseshoe bats. Plos Pathogens. 20(12).
3. Matae Ahn, Vivian Chih-Wei Chen, Pritisha Rozario, Wei Lun Ng, Pui San Kong, Wan Rong Sia, Adrian Eng Zheng Kang, Qi Su, Lan Huong Nguyen, Feng Zhu, Wharton OY Chan, Chee Wah Tan, Wan Shoo Cheong, Ying Ying Hey, Randy Foo, Fusheng Guo, Yan Ting Lim, Xin Li, Wan Ni Chia, Radoslaw M Sobota, Nai Yang Fu, Aaron T Irving, Lin-Fa Wang. 2023. Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases. Cell. 186 (10), 2144-2159. e22.
4. AT Irving*, M Ahn, G Goh, DE Anderson, LF Wang*. 2021. Lessons from the host defences of bats, a unique viral reservoir. Nature. 589 (7842), 363-370.
5. G Goh, M Ahn, F Zhu, LB Lee, D Luo, AT Irving*, LF Wang*. 2020. Complementary regulation of caspase-1 and IL-1β reveals additional mechanisms of dampened inflammation in bats. PNAS. 117 (46), 28939-28949.
6. Aaron T. Irving*, Qian Zhang, Pui-San Kong, Katarina Luko, Pritisha Rozario, Ming We , Feng Zhu, Peng Zhou, Justin H.J. Ng, Radoslaw M. Sobota, Lin-Fa Wang*. 2020. Interferon Regulatory Factors IRF1 and IRF7 Directly Regulate Gene Expression in Bats in Response to Viral Infection. Cell reports. 33 (5), 108345.
7. Aaron T. Irving*, Pritisha Rozario, Pui-San Kong, Katarina Luko, Jeffrey J. Gorman, Marcus L. Hastie, Wan Ni Chia, Shailendra Mani, Benjamin PY-H. Lee, Gavin J. D. Smith, Ian H. Mendenhall, H. Benjamin Larman, Stephen J. Elledge & Lin-Fa Wang*. 2020. Robust dengue virus infection in bat cells and limited innate immune responses coupled with positive serology from bats in IndoMalaya and Australasia. Cellular and Molecular Life Sciences. 77 (8), 1607-1622.
8. Matae Ahn, Danielle E. Anderson, Qian Zhang, Chee Wah Tan, Beng Lee Lim, Katarina Luko, Ming Wen, Wan Ni Chia, Shailendra Mani, Loo Chien Wang, Justin Han Jia Ng, Radoslaw M. Sobota, Charles-Antoine Dutertre, Florent Ginhoux, Zheng-Li Shi, Aaron T. Irving* & Lin-Fa Wang*. 2019. Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host. Nature Microbiology. 4 (5), 789-799.
9. A Banerjee*, AC Doxey, K Mossman, AT Irving*. 2021. Unravelling the zoonotic origin and transmission of SARS-CoV-2. Trends Ecol Evol. Mar;36(3):180-184.
10. Aaron T. Irving, Hitomi Mimuro, Thomas A. Kufer, Camden Lo, Richard Wheeler, Lorinda J. Turner, Belinda J. Thomas, Christian Malosse, Michael P. Gantier, Linda N. Casillas, Bartholomew J. Votta, John Bertin, Ivo G. Boneca, Chihiro Sasakawa, Dana J. Philpott, Richard L. Ferrero, Maria Kaparakis-Liaskos. 2014. The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling. Cell Host & Microbe. 15 (5), 623-635.
