研究简介
主要围绕呼吸系统发育与衰老、呼吸道相关疾病开展代谢组学及脂质组学的深度研究，包括开发多层次（“常规-痕量-单细胞水平”）的前沿组学分析方法及代谢流技术，开发深度代谢通路分析软件和多维度数据整合分析系统等前沿技术；应用前沿组学技术系统研究相关疾病的预警、诊断、预后及分型的生物标志物及代谢调控靶点，揭示代谢异常和呼吸道疾病的内在联系，挖掘相关疾病的重要功能代谢物，为呼吸道疾病的防治提供新线索和新策略。主持科技部国家重点研发计划、基金委重大研究计划集成项目和重点项目；已发表SCI论文>240篇，被引用>22,000余次（Google scholar), H index 78。
荣誉奖励
1. 国家重大人才项目科技创新领军人才
2. 中国科学院人才计划A类
代表性成果
1. Lam SM#, Wang Z#, Song JW#, Shi Y#, Liu WY#, Wan LY, Duan K, Chua GH, Zhou Y, Wang G, Huang X, Wang Y, Wang FS*, Zheng MH*, Shui G*. 2024. Non-invasive lipid panel of MASLD fibrosis transition underscores the role of lipoprotein sulfatides in hepatic immunomodulation. Cell Metabolism. In press (doi: 10.1016/j.cmet.2024.09.009).
2. Zheng J#, Lam SM#, Jiang B, Mao L, Liu J, Zhang Q, Yu M, Lim WLF, Tam CHT, Lowe WL Jr, Tam WH, Gao Y, Zhang J, Ma RCW*, Xiao X*, Shui G*. 2024. Cord blood ceramides facilitate early risk identification into childhood metabolic health. National Science Review. 11(10): nwae352.
3. Zhang L#, Zhao J#, Lam SM#, Chen L, Gao Y, Wang W, Xu Y, Tan T, Yu H, Zhang M, Liao X, Wu M, Zhang T, Huang J, Li B, Zhou QD, Shen N, Lee HJ, Ye C, Li D*, Shui G*, Zhang J*. 2024. Low-input lipidomics reveals lipid metabolism remodelling during early mammalian embryo development. Nature Cell Biology. 26(2):278-293.
4. Chen X#, Li J#, Gao Z, Yang Y, Kuang W, Dong Y, Chua GH, Huang X, Jiang B, Tian H, Wang Y, Huang X, Li Y, Lam SM*, Shui G*. 2022. Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural-glial coupling in Drosophila. National Science Review. 9(12): nwac148.
5. Lam SM#, Li J#, Sun H, Mao W, Lu Z, Zhao Q, Han C, Gong X, Jiang B, Chua GH, Zhao Z, Meng F*, Shui G*. 2022. Quantitative Lipidomics and Spatial MS-Imaging Uncovered Neurological and Systemic Lipid Metabolic Pathways Underlying Troglomorphic Adaptations in Cave-Dwelling Fish. Mol Biol Evol. 39(4): msac050.
6. Cao M, Zhang S, Lam SM, Shui G*. 2022. Hepatic loss of CerS2 induces cell division defects via a mad2-mediated pathway. Clinical Translational Medicine 12(1): e712
7. Tian H#, Ni Z#, Lam SM#, Jiang W, Li F, Du J*, Wang Y*, Shui G*. 2022. Precise Metabolomics Reveals a Diversity of Aging-Associated Metabolic Features. Small Methods. 6(7):e2200130.
8. Lam SM#, Zhang Chao#, Wang Z#, Ni Z# , Zhang S#, Yang S#, Huang X, Mo L, Li J, Lee B, Mei M, Huang L, Shi M, Xu Z, Meng FP, Cao WJ, Zhou MJ, Shi L, Chua GH, Li B, Cao J, Wang J, Bao S, Wang Y, Song JW*, Zhang F*, Wang FS*, Shui G*. 2021. A multi-omics investigation on the composition and function of extracellular vesicles along the temporal trajectory of COVID-19. Nature Metabolism: (7):909-922.
9. Wang X#, Lam SM#, Cao M#, Wang T, Wang Z, Yu M, Li B, Zhang H, Ping F, Song G, Feng K, Zhang Q, Xu J, Zhou L, Deng M, Zhai X, Xiao X*, Shui G*. 2021. Localized increases in CEPT1 and ATGL elevate plasmalogen phosphatidylcholines in HDLs contributing to atheroprotective lipid profiles in hyperglycemic GCK-MODY. Redox Biology. 40:101855.
10. Song JW#, Lam SM#, Fan X#, Cao WJ, Wang SY, Tian H, CHUA GH, Zhang C, Meng FP, Xu Z, Fu JL, Huang L, Xia P, Yang T, Zhang SH, Li BW, Jiang TJ, Wang RX, Wang ZH, Shi M, Zhang JY*, Wang FS*, Shui G*. 2020. Omics-driven systems interrogation of metabolic dysregulation in COVID-19 pathogenesis. Cell Metabolism. 32: 188-202.
