研究简介
长期从事无创、定量功能光学成像诊断技术的开发和临床应用。主要研究贡献是开发了微米光学相干层析(Micro-optical coherence tomography, µOCT) 技术， 以及基于µOCT的粘液纤毛清除在体成像检测技术。近期研究聚焦于呼吸道微米光学相干层析（EB-µOCT)内窥技术、粘液纤毛清除、小气道重塑、炎性反应定量在体成像诊断技术开发，以及光学成像技术在呼吸疾病精准、个体化诊断当中的应用。研究结果发表于Nature Medicine, American Journal of Respiratory Critical Care Medicine Optica, Photonix 等杂志，其中一作或通讯54篇。申报8项国际专利，授权6项，签订专利许可协议3项
荣誉奖励
1. 国家重大人才项目入选者
代表性成果
1. Linbo Liu, J.A. Gardecki, S.K. Nadkarni, J.D. Toussaint, Y. Yagi, B.E. Bouma and G.J. Tearney (2011). Imaging the Subcellular Structure of Human Coronary Atherosclerosis Using Micro-Optical Coherence Tomography, Nature Medicine 17, 1010-1014.
2. Linbo Liu, S. Shastry, S. Byan-Parker, G Houser, K. Chu, Susan E. Birket, Courtney M. Fernandez, J. A. Gardecki , W. Grizzle, E. J. Wilsterman, E. J. Sorscher, S. M. Rowe, G. J. Tearney (2014). An autoregulatory mechanism governing mucociliary transport is sensitive to mucus load, American Journal of Respiratory Cell and Molecular Biology, 51(4), 485-493
3. Susan E Birket, Kengyeh K Chu, Linbo Liu, Grace H Houser, Bradford J Diephuis, Eric J Wilsterman, Gregory Dierksen, Marina Mazur, Suresh Shastry, Yao Li, John D Watson, Alexander T Smith, Benjamin S Schuster, Justin Hanes, William E Grizzle, Eric J Sorscher, Guillermo J Tearney, Steven M Rowe (2014). A Functional Anatomic Defect of the Cystic Fibrosis Airway, American Journal of Respiratory and Critical Care Medicine, 190, 421-432
4. Dongyao Cui, Xinyu Liu, Jing Zhang, Xiaojun Yu, Sun Ding, Yuemei Luo, Jun Gu, Ping Shum, and Linbo Liu (2014). Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo, Optics Letters 39, 6727-6730.
5. Xinyu Liu, Xiaojun Yu, Hongying Tang, Dongyao Cui, Meghna R. Beotra, Michael J. A. Girard, Ding Sun, Jun Gu, and Linbo Liu (2014). Spectrally encoded extended source optical coherence tomography," Optics Letters 39, 6803-6806.
6. Dongyao Cui, Kengyeh Chu, Biwei Yin, Timothy N. Ford, Chulho Hyun, Hui Min Leung, Joseph A. Gardecki, George M. Solomon, Susan E. Birket, Linbo Liu, Steven M. Rowe, Guillermo J. Tearney (2017). Flexible, high-resolution µOCT endobronchial probe toward in vivo imaging of cilia, Optics Letters 42 (4), 867-870.
7. En Bo, Yuemei Luo, Si Chen, Xinyu Liu, Nanshuo Wang, Xin Ge, Xianghong Wang, Shufen Chen, Shi Chen, Jinhan Li, and Linbo Liu (2017). Depth of focus extension in optical coherence tomography via multiple aperture synthesis, Optica 4(7), 701-706.
8. Si Chen, Xin Ge, Xinyu Liu, Qianshan Ding, Nanshuo Wang, Xianghong Wang, Shufen Chen, Haitao Liang, Yunchao Deng, Qiaozhou Xiong, Guangming Ni, En Bo, Chenjie Xu Honggang Yuand Linbo Liu (2019), Understanding optical reflectance contrast for real‐time characterization of epithelial precursor lesions, Bioengineering & Translational Medicine, 4, e10137
9. En Bo, Xin Ge, Y0uemei Luo, Xuan Wu, Si Chen, Haitao Liang, Shufen Chen, Xiaojun Yu, Ping Shum, Jianhua Mo, Nanguang Chen & Linbo Liu (2020), Cellular-resolution in vivo tomography in turbid tissue through digital aberration correction. PhotoniX 1, 9.
10. Yukun Wang, Si Chen, Xi Chen, Zhengyang Xu, Kan Lin, Linlin Shi, Quanquan Mu, Linbo Liu (2024) Coaxial Bright and Dark Field Optical Coherence Tomography, IEEE Transactions on Biomedical Engineering, 71(6), 1879-1888.
