研究简介
主要研究方向为利用冷冻电镜单颗粒重构及其他生物化学方法，对呼吸系统中离子通道蛋白的结构和功能进行研究，以及应用冷冻电子断层扫描技术对呼吸系统中常见病原微生物的原位结构解析进行探索。
荣誉奖励
1.国家重大人才项目入选者（青年）
代表性成果
1. Zhang D#, Ivica J#, Krieger JM#, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH. (2023). Structural mobility tunes signaling of the GluA1 AMPA glutamate receptor. Nature 621: 877–882.
2. Zhang D#, Lape R#, Shaikh SA, Kohegyi BK, Watson JF, Cais O, Nakagawa T, Greger IH. (2023). Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics. Nat Commun 14(1):1659.
3. Zhang D, Watson JF, Matthews PM, Cais O, Greger IH. (2021). Gating and modulation of a hetero-octameric AMPA glutamate receptor. Nature 594: 454-458.
4. Zhang J#, Zhang D#, Sun L#, Ji G, Huang X, Niu T, Xu J, Ma C, Zhu Y, Gao N, Xu W, Sun F. (2021). VHUT-cryo-FIB, a method to fabricate frozen hydrated lamellae from tissue specimens for in situ cryo-electron tomography. J Struct Biol 213(3): 107763.
5. Zhang D#, Zhang Y#, Ma J, Niu T, Chen W, Pang X, Zhai Y and Sun F. (2020). Cryo-EM structures reveal a conformational change of SOPA1 during mitochondrial inner membrane fusion. Elife, 9:e50294.
