研究简介
免疫球蛋白是人体免疫系统的重要组成成分，它们识别并结合外源入侵的细菌、病毒等病原体，并通过多种途径介导免疫响应，从而保护机体免受侵害。李雅鑫博士过去的工作通过生物化学和结构生物学手段对免疫球蛋白进行了深入研究。阐明了人源IgM组装和黏膜转运的分子机制，改变了业内对IgM五聚体的传统理解。系统分析了FcμR受体识别不同形式IgM的分子机制，为深入理解IgM相关的免疫通路奠定基础。参与研究了分泌型IgA的组装机制，并揭示其被肺炎链球菌黏附蛋白识别的结构基础。未来实验室工作将聚焦于：
1. 免疫球蛋白与重要病原体蛋白的相互作用机制研究
2. Fc受体识别免疫球蛋白的分子机制研究
荣誉奖励
1. 国家重大人才项目青年拔尖人才；
2. 广州市重大人才项目青年拔尖人才；
代表性成果
1. Yaxin Li#, Hao Shen#, Ruixue Zhang#, Chenggong Ji, Yuxin Wang, Chen Su, and Junyu Xiao*. (2023) Immunoglobulin M perception by FcμR. Nature. 615(7954), 907-912.
2. Yaxin Li#, Guopeng Wang#, Ningning Li, Yuxin Wang, Qinyu Zhu, Huarui Chu, Wenjun Wu, Ying Tan, Feng Yu, Xiao-Dong Su, Ning Gao, and Junyu Xiao*. (2020) Structural insights into immunoglobulin M. Science. 367(6481), 1014-1017.
3. Yuxin Wang#, Guopeng Wang#, Yaxin Li#, Qinyu Zhu, Hao Shen, Ning Gao, and Junyu Xiao*. (2020) Structural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin. Cell Research. 30(7), 602-609.
4. Xiangzhong Sun#, Yaxin Li#, Wenrong He, Chenggong Ji, Peixue Xia, Yichuan Wang, Shuo Du, Hongjiang Li, Natasha Raikhel, Junyu Xiao* and Hongwei Guo*. (2017) Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase. Nature Communications. 8:15758.
5. Chenggong Ji#, Hao Shen#, Chen Su, Yaxin Li, Shihua Chen, Thomas Sharp and Junyu Xiao*. (2023) Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M. Nature Communications. 14(1):2650. # Co-first author, * Corresponding author.
