研究简介
长期致力于结合电生理、分子生物学和生物化学等手段研究离子通道的结构、功能及调节机制。尤其专注于Cl-和Ca2+离子通道的结构和生理功能的分子机制研究。特别是在TRP通道调控胞内钙信号进而影响细胞代谢的生理机制方面较有成果。同时，在纳米脂质体和中药组分对巨噬细胞功能影响方面也较有研究。目前已累计在包括Nat. Cell Biol.和Nat. Struct. Mol. Biol.等较有影响力的SCI期刊中以第一或通讯作者身份发表近10篇科研论文，主持及参与多项国家基金，并申报多项专利。
荣誉奖励
2015年获得由湖北省教育厅授予的湖北省“楚天学者”楚天学子称号。
代表性成果
1. Wan-Li Liang,Yanzhang Wen,Fang Huang,Qin Hu,Xiao-Jun Li,Wei Kevin Zhang*,Xinzhou Yang*.2020.Chrysanthemum ethanol extract induced loss of Kupffer cells via the mitochondria-dependent apoptotic pathway.Food Funct.11(10):8866-8877.
2. Huiqi Huang,Ji Hao,Kejian Pang,Yibing Lv,Dingrong Wan,Chaoqun Wu,Yuanren Ma,Xinzhou Yang*.2020.A biflavonoid-rich extract from Selaginella moellendorffii Hieron. induces apoptosis via STAT3 and Akt/NF-κB signalling pathways in laryngeal carcinoma.J Cell Mol Med.24(20):11922-11935.
3. Wan-Li Liang,Lan Xiao,Hong-Wei Gu,Xiao-Jun Li,Yu-Sang Li,Wei Kevin Zhang*,He-Bin Tang*.2019.Solid lipid nanoparticle induced apoptosis of macrophages via a mitochondrial-dependent pathway in vitro and in vivo.Int J Nanomedicine.14:3283 3295.
4. Dan Ning#,Wei Kevin Zhang#,Han Tian,Xiao-Jun Li,Min Liu,Yu-Sang Li,He-Bin Tang.2017.The Involvement of β-Catenin/COX-2/VEGF Axis in NMDA-Caused Retinopathy.J Ophthalmol.2017:9760501.
5. Minghui Li#,Wei K Zhang#,Nicole M Benvin#,Xiaoyuan Zhou,Deyuan Su,Huan Li,Shu Wang,Ioannis E Michailidis,Liang Tong,Xueming Li,Jian Yang.Structural basis of dual Ca2+/pH regulation of the endolysosomal TRPML1 channel.2017.Nat Struct Mol Biol.24(3):205-213.
6. Wei Kevin Zhang,Hong-Wei Gu,Xiao-Jun Li,Yu-Sang Li,He-Bin Tang,Gui-Hua Tian,Hong-Cai Shang.2017.The dark side of "the force" - lipid nanoparticles enhance the oncogenesis of diethylnitrosamine and result in liver cancer in mice.Nanomedicine.13(2):701-711.
7. Wei Kevin Zhang,Shan-Shan Tao,Ting-Ting Li,Yu-Sang Li,Xiao-Jun Li,He-Bin Tang,Ren-Huai Cong,Fang-Li Ma,Chu-Jun Wan.2016.Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release in vivo.Food Nutr Res.60:30849.
8. Wei Kevin Zhang,Dong Wang,Yuanyuan Duan,Michael M T Loy.2010.Mechanosensitive gating of CFTR.Nat Cell Biol. 12(5):507-12.
9. 肝脏诱癌剂及其制备方法.中国专利.CN201610024291.7.2016-05-04.4.
10. 一种高效液相色谱分离六神丸紫外吸收成分的方法.中国专利.CN201611263394.5.2017-03-08.5.
