李筝研究员
教育经历
2005.09-2009.06，华东师范大学，生物技术，本科
2009.09-2016.01，中国科学院大学，生物化学与分子生物学，研究生
工作经历
2016.02-2020.06，耶鲁大学，博士后
2020.06-2020.09，耶鲁大学，Associate Research Scientist
2020.11-2021.05，生物岛实验室，研究员
2021.05至今，广州实验室，研究员
2022.10至今，广州医科大学，教授（兼职）
研究简介
李筝，广州实验室研究员，国家重大人才项目（青年）入选者。中国科学院大学（上海生化细胞所）博士，耶鲁大学博士后。专注于DNA修饰介导的表观遗传调控机制与功能方面研究，代表性研究成果以第一作者/共同第一作者身份发表在Nature、Nucleic Acids Research等国际期刊上，亦作为合作作者在Cell、Science、Cell Stem Cell及Cell Research等杂志发表多篇论文。目前主要研究DNA修饰等表观遗传因子在呼吸系统疾病发生发展中的作用和分子机制。具体包括：呼吸系统疾病的表观遗传调控机制；肺细胞分化过程中的表观遗传调控；基因组上DNA修饰建立与调控的分子机制等。主持国家自然科学基金面上项目1项，指导课题组博士后获得博士后科学基金面上资助1项。
人才头衔与荣誉奖励
1.国家重大人才项目入选者（青年） 2022年
代表性成果
1.Li, Zheng#; Zhao, Shuai#; Nelakanti, Raman V.#; Lin, Kaixuan#; Wu, Tao P.#; Alderman, Myles H.; Guo, Cheng; Wang, Pengcheng; Zhang, Min; Min, Wang; Jiang, Zongliang; Wang, Yinsheng; Li, Haitao; Xiao, Andrew Z. 2020. N6-methyladenine in DNA antagonizes SATB1 in early Development. Nature. 583(7817),625-630
2.Li, Zheng#; Li, Li#; Zhang, Haifeng; Zhou, Huanjiao Jenny; Ji, Weidong; Min, Wang. 2020. Short AIP1 (ASK1-Interacting Protein-1) Isoform Localizes to the Mitochondria and Promotes Vascular Dysfunction. Arteriosclerosis, Thrombosis, and Vascular Biology. 40(01), 112-127
3.Zhang, Min#; Yang, Shumin#; Nelakanti, Raman#; Zhao, Wentao; Liu, Gaochao; Li, Zheng; Liu, Xiaohui; Wu, Tao; Xiao, Andrew; Li, Haitao. 2020. Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA. Cell Research. 30(3), 197-210
4.Xie, Qi#; Gimple, Ryan C#.;Wu, Tao P.#;Li, Zheng; Prager, Briana C.; Wu, Qiulian; Yu, Yang; Wang, Pengcheng; Wang, Yinsheng; Gorkin, David U.; Zhang, Cheng; Dowiak, Alexis V.; Lin, Kaixuan; Zeng, Chun; Sui, Yinghui; Kim, Leo J.Y.; Miller, Tyler E.; Jiang, Li; Lee, Christine H.; Huang, Zhi; Fang, Xiaoguang; Zhai, Kui; Mack, Stephen C.; Sander, Maike; Bao, Shideng; Kerstetter-Fogle, Amber E.; Sloan, Andrew E.; Xiao, Andrew Z.*; Rich, Jeremy N.*. 2018. N6-methyladenine DNA Modification in Glioblastoma. Cell. 175(5), 1228–1243
5.Jin, Seung Gi;Zhang, Zhi Min;Dunwell, Thomas L.;Harter, Matthew R.;Wu, Xiwei;Johnson, Jennifer;Li, Zheng; Liu, Jiancheng; Szabó, Piroska E.; Lu, Qiang; liang Xu, Guo; Song, Jikui; Pfeifer, Gerd P. 2016. Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration. Cell Reports. 14(3), 493–505
6.Li, Zheng; Gu, Tian-Peng; Weber, Alain R.; Shen, Jia-Zhen; Li, Bin-Zhong; Xie, Zhi-Guo; Yin, Ruichuan; Guo, Fan; Liu, Xiaomeng; Tang, Fuchou; Wang, Hailin; Schär, Primo; Xu, Guo-Liang. 2015. Gadd45a promotes DNA demethylation through TDG. Nucleic Acids Research. 43(08), 3986–3997
7.Hu, Xiao;Zhang, Lei#;Mao, Shi-Qing#;Li, Zheng; Chen, Jiekai; Zhang, Run-Rui; Wu, Hai-Ping; Gao, Juan; Guo, Fan; Liu, Wei; Xu, Gui-Fang; Dai, Hai-Qiang; Shi, Yujiang Geno; Li, Xianlong; Hu, Boqiang; Tang, Fuchou; Pei, Duanqing; Xu, Guo-Liang. 2014. Tet and TDG Mediate DNA Demethylation Essential for Mesenchymal-to-Epithelial Transition in Somatic Cell Reprogramming. Cell Stem Cell. 14(04), 512–522
8.Yin, Ruichuan;Mao, Shi Qing;Zhao, Bailin;Chong, Zechen;Yang, Ying;Zhao, Chao;Zhang, Dapeng;Huang, Hua;Gao, Juan;Li, Zheng; Jiao, Yan; Li, Cuiping; Liu, Shengquan; Wu, Danni; Gu, Weikuan; Yang, Yun Gui; Xu, Guo Liang; Wang, Hailin. 2013. Ascorbic acid enhances tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals. Journal of the American Chemical Society. 135(28), 10396–10403
9.Xu, Shutong;Li, Wenjing;Zhu, Junjun;Wang, Rong;Li, Zheng; Xu, Guo-Liang; Ding, Jianping. 2013. Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase. Cell Research. 23(11), 1296-1309
10.He, Yu-Fei;Li, Bin-Zhong#;Li, Zheng; Liu, Peng; Wang, Yang; Tang, Qingyu; Ding, Jianping; Jia, Yingying; Chen, Zhangcheng; Li, Lin; Sun, Yan; Li, Xiuxue; Dai, Qing; Song, Chun-Xiao; Zhang, Kangling; He, Chuan; Xu, Guo-Liang. 2011. Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA. Science. 333(6047), 1303-1307