索生宝研究员
教育经历
2006.09-2010.07，南昌大学，应用化学，本科
2010.09-2013.06，南昌大学，分析化学，硕士研究生
2013.09-2017.07，中国科学院大学，计算生物学，博士研究生
工作经历
2017.07-2021.09，丹娜-法伯癌症研究生/哈佛大学，博士后
2021.09-2021.12，生物岛实验室，研究员
2022.01-至今，广州实验室，研究员，博士生导师
2022.10-至今，广州医科大学/呼吸疾病全国重点实验室，特聘教授（兼职）
研究简介
课题组主要从事以实验手段为支撑，以大数据解析为主导的基础与临床相结合的多学科融合研究工作，主要研究领域包含：1）结合单细胞时空多组学数据系统性构建复杂组织细胞间时空调控网络；2）肿瘤早期演进规律及抗肿瘤免疫治疗机制研究；3）机器学习等算法的开发及其在疾病模型中的应用。
人才头衔与荣誉奖励
“2019年中国生命科学十大进展”、“2019年中国生物信息学十大进展”及“2019年中国生物信息学十大应用”
代表性成果
1.Fangfang Qu^; Wenjia Li^; Jian Xu^; Ruifang Zhang; Jincan Ke; Xiaodie Ren; Xiaogao Meng; Lexin Qin; Jingna Zhang; Fangru Lu; Xin Zhou; Xi Luo; Zhen Zhang; Minhan Wang; Guangming Wu; Duanqing Pei; Jiekai Chen; Guizhong Cui#; Shengbao Suo#; Guangdun Peng#. 2023. Three-dimensional molecular architecture of mouse organogenesis. Nature Communications. 14(1):4599.
2.Renying Wang^; Peijing Zhang^#; Jingjing Wang^; Lifeng Ma^; Weigao E^; ShengBao Suo^; Mengmeng Jiang^; Jiaqi Li^; Haide Chen; Huiyu Sun; Lijiang Fei; Ziming Zhou; Yincong Zhou; Yao Chen; Weiqi Zhang; Xinru Wang; Yuqing Mei; Zhongyi Sun; Chengxuan Yu; Jikai Shao; Yuting Fu; Yanyu Xiao; Fang Ye; Xing Fang; Hanyu Wu; Qile Guo; Xiunan Fang; Xia Li; Xianzhi Gao; Dan Wang; Peng-Fei Xu; Rui Zeng; Gang Xu; Lijun Zhu; Lie Wang; Jing Qu; Dan Zhang; Hongwei Ouyang; He Huang; Ming Chen; Shyh-Chang NG#; Guang-Hui Liu#; Guo-Cheng Yuan#; Guoji Guo#; Xiaoping Han#. 2023. Construction of a cross-species cell landscape at single-cell level. Nucleic Acids Research. 51(2):501-516.
3.Adrienne M. Luoma^; Shengbao Suo^#; Yifan Wang; Lauren Gunasti; Caroline B.M. Porter; Nancy Nabilsi; Jenny Tadros; Andrew P. Ferretti; Sida Liao; Cagan Gurer; Yu-Hui Chen; Shana Criscitiello; Cora A. Ricker; Danielle Dionne; Orit Rozenblatt Rosen; Ravindra Uppaluri; Robert I. Haddad; Orr Ashenberg; Aviv Regev; Eliezer M. Van Allen; Gavin MacBeath; Jonathan D. Schoenfeld#; Kai W. Wucherpfennig#. 2022. Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy. Cell. 185(16):2918-2935.
4.Adrienne M. Luoma^; Shengbao Suo^; Hannah L. Williams; Tatyana Sharova; Keri Sullivan; Michael Manos; Peter Bowling; F. Stephen Hodi; Osama Rahma; Ryan J. Sullivan; Genevieve M. Boland; Jonathan A. Nowak; Stephanie K. Dougan; Michael Dougan#; Guo-Cheng Yuan; Kai W. Wucherpfennig#. 2020. Molecular pathways of colon inflammation induced by cancer immunotherapy. Cell. 182(3):655-671.
5.Guangdun Peng^#; Shengbao Suo^; Guizhong Cui^; Fang Yu^; Ran Wang; Jun Chen; Shirui Chen; Zhiwen Liu; Guoyu Chen; Yun Qian; Patrick P.L.Tam; Jing-Dong J.Han#; Naihe Jing#. 2019. Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature. 572(7770):528-532.
6.Shengbao Suo; Qian Zhu; Assieh Saadatpour; Lijiang Fei; Guoji Guo; Guo-Cheng Yuan#. 2018. Revealing the critical regulators of cell identity in the mouse cell atlas. Cell Reports. 6(25):1436-1445.
7.Guizhong Cui^; Shengbao Suo^; Ran Wang; Yun Qian; Jing-Dong J. Han#; Guangdun Peng#; Patrick P. L. Tam#; Naihe Jing#. 2018. Mouse gastrulation:Attributes of transcription factor regulatory network for epiblast patterning. Development, Growth & Differentiation. 60(8):463-472.
8.Jun Chen^; Shengbao Suo^; Patrick PL Tam; Jing-Dong J Han#; Guangdun Peng#; Naihe Jing#. 2017. Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq. Nature Protocols. 12(3):566-580.
9.Guangdun Peng^; Shengbao Suo^; Jun Chen^; Weiyang Chen; Chang Liu; Fang Yu; Ran Wang; Shirui Chen; Na Sun; Guizhong Cui; Lu Song; Patrick P.L. Tam; Jing-Dong J.Han#; Naihe Jing#. 2016. Spatial transcriptome for the molecular annotation of lineage fates and cell identity in mid-gastrula mouse embryo. Developmental Cell. 36(6):681-697.
10.Sheng-Bao Suo; Jian-Ding Qiu#; Shao-Ping Shi; Xiang Chen; Shu-Yun Huang; Ru-Ping Liang. 2013. Proteome-wide analysis of amino acid variations that influences protein lysine acetylation. Journal of Proteome Research. 12(2):949-958.