王凡研究员
教育经历
1984-1988，吉林大学，物理学，学士
1988-1991，吉林大学，生物化学，硕士
1994-1997，中国原子能科学研究院，同位素技术，博士
工作经历
1998-2000，美国橡树岭国家实验室，华盛顿大学医学院，博士后
1991-2008，中国原子能科学研究院，助理研究员/副研究员/研究员
2001至今，北京大学医学部，教授
2013至今，中国科学院生物物理研究所，客座研究员
2021至今，广州实验室，研究员
研究简介
分子影像是近年来发展十分迅速的一个交叉学科，它是应用影像学方法，对活体状态下的生物过程进行细胞和分子水平的定性和定量研究，涉及生物学、基础医学、临床医学、化学、物理学、药学等多个学科，具有无创、实时、动态、特异等特点，被美国医学会评为未来最具有发展潜力的十个医学科学前沿领域之一。分子探针的研究是分子影像领域的核心，本课题组针对疾病特别是肿瘤在不同发展阶段的特异性标志物设计构建分子探针，在完成临床前动物显像的基础上进行临床转化研究，进行疾病的早期诊断、分期、预后、疗效评价以及个体化治疗。
人才头衔与荣誉奖励
1.2011年 国家“杰出青年科学基金”
2.2008年 美国核医学学会Berson-Yalow奖
代表性成果
1.Shi Jiyun#, Du Shuaifan#, Wang Rongxi#, Gao Hannan, Luo Qi, Hou Guozhu, Zhou Yidong*, Zhu Zhaohui*, and Wang Fan*. 2023. Molecular Imaging of HER2 Expression in Breast Cancer Patients Using a Novel Peptide‑based Tracer 99mTc‑HP‑Ark2: a Pilot Study. Journal of Translational Medicine. 21(1): 1-17.
2.Gao Yu#, Luo Qi#, Sun Zhichen, Gao Hannan, Yu Yue, Sun Yining, Ma Xiaotu, Han Chuanhui, Shi Jiyun*, and Wang Fan*. 2023. Implication of 99mTc-sum IL-2 SPECT/CT in Immunotherapy by Imaging of Tumor-infiltrating T Cells. Journal for ImmunoTherapy of Cancer. 11(3): e005925.
3.Zhao Haitao#, Gao Hannan#, Luo Chuangwei, Yang Guangjie, Zhao Xiaoyu, Gao Shi, Ma Qingjie, Jia Bing, Shi Jiyun*, and Wang Fan*. 2021. An Integrin-αvβ6/α5β1-Bitargeted Probe for the SPECT Imaging of Pancreatic Adenocarcinoma in Preclinical and Primary Clinical Studies. Bioconjugate Chemistry. 32(7): 1298-1305.
4.Gao Hannan#, Wu Yue#, Shi Jiyun#, Zhang Xin, Liu Tianyu, Hu Biao, Jia Bing, Wan Yakun, Liu Zhaofei, and Wang Fan*. 2020. Nuclear Imaging-Guided PD-L1 Blockade Therapy Increases Effectiveness of Cancer Immunotherapy. Journal for ImmunoTherapy of Cancer. 8(2): e001156.
5.Gao Shi#, Jia Bing#, Feng Guokai#, Dong Chengyan, Du Hui, Bai Lin, Zhong Qian, Ma Qingjie*, Zeng Musheng*, and Wang Fan*. 2020. First-in-human Pilot Study of an Integrin α6-targeted Radiotracer for SPECT Imaging of Breast Cancer. Signal Transduction and Targeted Therapy. 5(1):147-149.
6.Wu Yue#, Li Liqiang#, Wang Zihua, Shi Jiyun, Hu Zhiyuan, Gao Shi, Miao Weibing, Ma Qingjie, Dong Chengyan*, and Wang Fan*. 2020. Imaging and Monitoring HER2 Expression in Breast Cancer During Trastuzumab Therapy with a Peptide Probe 99mTc-HYNIC-H10F. European Journal of Nuclear Medicine and Molecular Imaging. 47: 2613-2623.
7.Li Liqiang#, Wu Yue#, Wang Zihua, Jia Bing, Hu Zhiyuan, Dong Chengyan*, and Wang Fan*. 2017. SPECT/CT Imaging of the Novel HER2-targeted Peptide Probe 99mTc-HYNIC-H6F in Breast Cancer Mouse Models. Journal of Nuclear Medicine. 5 (5): 821-826.
8.Yu Xinhe, Wu Yue, Liu Hao, Gao Liquan, Sun Xianlei, Zhang Chenran, Shi Jiyun, Zhao Huiyun, Jia Bing, Liu Zhaofei, and Wang Fan*. 2016. Small-Animal SPECT/CT of the Progression and Recovery of Rat Liver Fibrosis by Using an Integrin αvβ3 targeting Radiotracer. Radiology. 279(2): 502-512.
9.Zhu Zhaohui, Miao Weibing, Li Qianwei, Dai Haojie, Ma Qingjie, Wang Feng, Yang Aiming, Jia Bing, Jing Xiaona, Liu Sha, Shi Jiyun, Liu Zhaofei, Zhao Zhoushe, Wang Fan*, and Li Fang*. 2012. 99mTc-3PRGD2 for Integrin Receptor Imaging of Lung Cancer: a Multi-Center Study. Journal of Nuclear Medicine. 53(5): 716-722.
10.Jia Bing, Shi Jiyun, Yang Zhi, Xu Bing, Liu Zhaofei, Zhao Huiyun, Liu Shuang*, and Wang Fan*. 2006. 99mTc-Labeled Cyclic RGDfK Dimer: Initial Evaluation for SPECT Imaging of Glioma Integrin αvβ3 Expression. Bioconjugate Chemistry. 17(4): 1069-1076.