马显才研究员
教育经历
2010.08-2014.06，中山大学，生物科学，本科
2014.07-2019.06，中山大学，微生物学，博士研究生
工作经历
2019.07-2021.10，中山大学中山医学院，博士后
2022.01至今，广州实验室，研究员
2022.10至今，广州医科大学附属第一医院，特聘教授（兼职）
研究简介
马显才研究员专注于进行病毒与宿主互作分子免疫学机制研究。并以机制为导向进行多系统的抗病毒药物筛选工作和高滴度的纳米颗粒疫苗研发工作。在新冠病毒纳米颗粒疫苗研究、抗新冠病毒药物研究和HIV-1潜伏感染机制研究中取得了一系列学术成绩。研究成果发表在Immunity、Signal Transduction and Targeted Therapy、EMBO Journal、Cellular & Molecular Immunology、eLife、EMBO Reports等国际学术期刊上。近五年在国际著名期刊发表高水平研究论文30余篇，其中通讯/第一作者论文12篇，4篇IF＞10，总引用次数1440余次。授权抗病毒药物发明专利1项、纳米颗粒疫苗专利4项。主持国家自然科学基金、“十三五”国家科技重大专项子课题等基金项目8项。担任中国疫苗行业协会委员，以及Signal Transduction and Targeted Therapy、Medical Microbiology and Immunology等杂志的审稿人。
人才头衔与荣誉奖励
1. 国家重大人才项目青年拔尖人才入选者
2. 辽宁医学科技奖
3. 沈阳市自然科学学术成果奖
代表性成果
1.Ma, Xiancai#; Zou, Fan#; Yu, Fei#; Li, Rong#; Yuan, Yaochang#; Zhang, Yiwen#; Zhang, Xiantao; Deng, Jieyi; Chen, Tao; Song, Zheng; Qiao, Yidan; Zhan, Yikang; Liu, Jun; Zhang, Junsong; Zhang, Xu; Peng, Zhilin; Li, Yuzhuang; Lin, Yingtong; Liang, Liting; Wang, Guanwen; Chen, Yingshi; Chen, Qier; Pan, Ting; He, Xin; Zhang, Hui*.2020.Nanoparticle vaccines based on the receptor binding domain (RBD) and heptad repeat (HR) of SARS-CoV-2 elicit robust protective immune responses.Immunity.53(6): 1315-1330.e9
2.Ma, Xiancai#; Chen, Tao; Peng, Zhilin; Wang, Ziwen; Liu, Jun; Yang, Tao; Wu, Liyang; Liu, Guangyan; Zhou, Mo; Tong, Muye; Guan, Yuanjun; Zhang, Xu; Lin, Yingtong; Tang, Xiaoping; Li, Linghua; Tang, Zhonghui; Pan, Ting; Zhang, Hui*.2021.Histone chaperone CAF-1 promotes HIV-1 latency by leading the formation of phase-separated suppressive nuclear bodies.The EMBO Journal.19(2)
3.Wu, Liyang#; Pan, Ting#; Zhou, Mo; Chen, Tao; Wu, Shiyu; Lv, Xi; Liu, Jun; Yu, Fei; Guan, Yuanjun; Liu, Bingfeng; Zhang, Wanying; Deng, Xiaohui; Chen, Qianyu; Liang, Anqi; Lin, Yingtong; Wang, Lilin; Tang, Xiaoping; Cai, Weiping; Li, Linghua; He, Xin; Zhang, Hui*; Ma, Xiancai*.2022.CBX4 contributes to HIV-1 latency by forming phase-separated nuclear bodies and SUMOylating EZH2. EMBO Reports.23(7)
4.Ma, Xiancai#; Yang, Tao; Luo, Yuewen; Wu, Liyang; Jiang, Yawen; Song, Zheng; Pan, Ting; Liu, Bingfeng; Liu, Guangyan; Liu, Jun; Yu, Fei; He, Zhangping; Zhang, Wanying; Yang, Jinyu; Liang, Liting; Guan, Yuanjun; Zhang, Xu; Li, Linghua; Cai, Weiping; Tang, Xiaoping; Gao, Song; Deng, Kai; Zhang, Hui*.2019.TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb.eLife.8
5.Yu, Fei#; Pan, Ting#; Huang, Feng#; Ying, Ruosu; Liu, Jun; Fan, Huimin; Zhang, Junsong; Liu, Weiwei; Lin, Yingtong; Yuan, Yaochang; Yang, Tao; Li, Rong; Zhang, Xu; Lv, Xi; Chen, Qianyu; Liang, Anqi; Zou, Fan; Liu, Bingfeng; Hu, Fengyu; Tang, Xiaoping; Li, Linghua; Deng, Kai; He, Xin; Zhang, Hui; Zhang, Yiwen; Ma, Xiancai*.2022. Glycopeptide Antibiotic Teicoplanin Inhibits Cell Entry of SARS-CoV-2 by Suppressing the Proteolytic Activity of Cathepsin L.Frontiers in Microbiology.13
6.Liang, Taizhen#; Li, Guojie#; Lu, Yunfei; Hu, Meilin; Ma, Xiancai*.2023.The Involvement of Ubiquitination and SUMOylation in Retroviruses Infection and Latency.Viruses.15(4): 985
7.Pan, Ting#; Chen, Ran#; He, Xin#; Yuan, Yaochang#; Deng, Xiaohui; Li, Rong; Yan, Haiping; Yan, Shumei; Liu, Jun; Zhang, Yiwen; Zhang, Xiantao; Yu, Fei; Zhou, Mo; Ke, Changwen; Ma, Xiancai*; Zhang, Hui*.2021.Infection of wild-type mice by SARS-CoV-2 B.1.351 variant indicates a possible novel cross-species transmission route.Signal Transduction and Targeted Therapy. 6(1)
8.Li, Rong#; Ma, Xiancai#; Deng, Jieyi; Chen, Qier; Liu, Weiwei; Peng, Zhilin; Qiao, Yidan; Lin, Yingtong; He, Xin*; Zhang, Hui*.2021.Differential efficiencies to neutralize the novel mutants B.1.1.7 and 501Y.V2 by collected sera from convalescent COVID-19 patients and RBD nanoparticle-vaccinated rhesus macaques.Cellular and Molecular Immunology.21(8): 1-3
9.Xu, Xinfeng#; Lin, Yingtong#; Zeng, Xiaoyun; Yang, Chan; Duan, Siqin; Ding, Liqiong; Lu, Wanzhen; Lin, Jian; Pan, Xiaoyan; Ma, Xiancai*; Liu, Shuwen*.2022.PARP1 Might Substitute HSF1 to Reactivate Latent HIV-1 by Binding to Heat Shock Element.Cells.11(15)
10.Liu, Sen#; Liang, Haojun#; Lv, Linwen; Hu, Fan; Liu, Qiuyang; Wang, Yujiao; Zhu, Junyu; Chen, Ziteng; Li, Jiacheng; Wang, Zhijie; Chang, Yanan; Li, Juan; Ma, Xiancai*; Chen, Kui*; Xing, Gengmei*.2023.3D culture boosting fullerenol nanoparticles to induce calreticulin exposure on MCF-7 cells for enhanced macrophage-mediated cell removal.Colloids and Surfaces B: Biointerfaces.224: 113204