丁彬彬研究员

教育经历
2007.09-2011.06，华中农业大学生命科学与技术学院，生物工程，本科
2011.09-2016.06，武汉大学生命科学学院/病毒学国家重点实验室，病毒学，博士
 
工作经历
2016.07-2017.01，St. Jude Children’s research hospital, Memphis, TN, USA，博士后
2017.02-2019.08，UT Southwestern Medical Center, Dallas, TX, USA，博士后
2019.09-2023.12，华中科技大学同济医学院基础医学院，教授，博士生导师
2024.01至今，广州实验室，研究员                        
 
研究简介
细胞将具有特定生化功能的内部划分为独立的个体，形成细胞器。膜性细胞器会通过物理接触来行使功能。在病毒感染的细胞中，病毒编码的蛋白可劫持细胞器，调控细胞中各个细胞器互作，激活细胞器应激反应，重塑细胞内部环境，为病毒的顺利复制提供适合的场所。但是对与病毒是如何调控细胞器互作，如何劫持特定的细胞器功能和激活细胞应激反应还有待更深入的研究；哪些关键蛋白（病毒蛋白和细胞蛋白）可以调控细胞器互作还有待进一步鉴定。本人课题组运用病毒学、细胞生物学、生物化学等技术手段，以哺乳动物细胞系和小鼠为模型，研究病毒调控细胞器互作、细胞自噬、细胞应激反应的分子机制和生理功能。
 
人才头衔与荣誉奖励
1.国家优秀青年科学基金
2.湖北省“百人计划” 
 
代表性成果
1.Zhen Yuan; Kun Cai; Jiajia Li; Ruifeng Chen; Fuhai Zhang, Xuan Tan, Yaming Jiu, Haishuang Chang, Bing Hu, Weiyi Zhang; Binbin Ding*. ATG14 Targets Lipid Droplets and Acts as An Autophagic Receptor for Syntaxin18 Regulated Lipid Droplet Turnover. Nature Communications, 2024 Jan 20;15(1):631. 
 
2.Mengzhen Yue; Bing Hu; Jiajia Li; Ruifeng Chen; Zhen Yuan; Hurong Xiao; Haishuang Chang; Yaming Jiu; Kun Cai; Binbin Ding*. Coronaviral ORF6 Protein Mediates Inter-Organelle Contacts and Modulates Host Cell Lipid Flux for Virus Production. The EMBO Journal, 2023 Jul 3;42(13): e112542.
 
3.Xuan Tan; Kun Cai; Jiajia Li; Zhen Yuan; Ruifeng Chen; Hurong Xiao; Chuanrui Xu; Bing Hu; Yali Qin*; Binbin Ding*. Coronavirus Subverts ER-phagy by Hijacking FAM134B and ATL3 into p62 Condensates to Facilitate Viral Replication. Cell Reports, 2023, 42(4): 112286. 
 
4.Zhen Yuan; Bing Hu; Hurong Xiao; Xuan Tan; Yan Li; Ke Tang; Yonghui Zhang; Kun Cai; Binbin Ding*. The E3 Ubiquitin Ligase RNF5 Facilitates SARS-CoV-2 Membrane Protein-Mediated Virion Release, mBio, 2022 Feb 1;13(1): e0316821. 
 
5.Yuhui Fu#; Binbin Ding#, *; Xiaoxia Liu#, *; Shangang Zhao; Fang Chen; Linsen Li; Yi Zhu; Jingxuan Zhao; Zhen Yuan; Yafeng Shen; Chaofeng Yang; Mengle Shao; She Chen; Perry E. Bickel; Qing Zhong*. Qa SNARE Syntaxin 18 (STX18) Mediates Lipid Droplet Fusion with SNAP23 and SEC22B. Cell Discovery, 2023 Nov 21;9(1):115. 
 
6.Binbin Ding; Qing Zhong*. Zinc deficiency: An unexpected trigger for autophagy, J. Biol. Chem, 2017, 292(20): 8531-8532.
 
7.Binbin Ding; Linliang Zhang; Zhifei Li; Yi Zhong; Qiaopeng Tang; Yali Qin; Mingzhou Chen*. The Matrix Protein of Human Parainfluenza Virus Type 3 Induces Mitophagy that Suppresses Interferon Responses, Cell Host & Microbe, 2017, 21(4): 538-547. 
 
8.Binbin Ding; Guangyuan Zhang; Xiaodan Yang; Shengwei Zhang; Longyun Chen; Qin Yan; Mengyao Xu; Amiya K. Banerjee; Mingzhou Chen*. Phosphoprotein of Human Parainfluenza Virus Type 3 Blocks Autophagosome-Lysosome Fusion to Increase Virus Production, Cell Host & Microbe, 2014, 15(5): 564-577.