胡文祥研究员
教育经历
2004.09-2008.07，中国科学技术大学，生物技术，学士
2008.09-2014.07，中科院上海生物化学与细胞研究所，细胞生物学，博士
工作经历
2014.07-2015.05，中科院上海生物化学与细胞研究所，助理研究员
2015.06-2016.03，美国德州大学西南医学中心，博士后
2016.04-2021.04，美国宾夕法尼亚大学医学院，博士后
2021.05至今，广州实验室，研究员
研究简介
主要致力于应用干细胞与功能基因组学研究慢性呼吸系统疾病和代谢疾病的发生机制和药物的精准医疗，相关研究成果以主要作者发表于Cell Metabolism, Cell Stem Cell (2015, 2019), Cell Research, Genes & Development 和 JBC。并受邀以通讯作者（含共同）在Nature Reviews Endocrinology和SCIENTIA SINICA Vitae撰写综述文章。以共同作者在Cell, Science, Neuron和PNAS等国际著名期刊发表多篇文章。文章总引用逾1300次。目前作为课题负责人主持国家自然科学基金面上项目1项。课题组研究方向为：
1、慢性呼吸系统疾病的代谢调控机制
2、慢性呼吸系统疾病发生的遗传与表观遗传基础
3、肺脏类器官模型的优化，研究药物的精准医疗
人才头衔与荣誉奖励
入选国家重大人才项目（青年）、广东省重大人才项目青年拔尖人才、广州市黄埔区精英人才，曾荣获2022年美国十大医学进展提名奖、国际干细胞研究年会杰出奖及旅行奖、美国糖尿病协会博士后基金、中国科学技术大学最高奖学金郭沫若奖学金、国家奖学金等奖项。
代表性成果
1. Wenxiang Hu*, Mitchell Lazar*. Modelling metabolic diseases and drug response using stem cells and organoids. Nature Reviews Endocrinology, 2022 Sep 7:1-16.
2. Wenxiang Hu*#, Chunjie Jiang#, Mindy Kim, Yang Xiao, Hannah J. Richter, Dongyin Guan, Kun Zhu,Brianna M Krusen, Arielle N. Roberts, Jessica Miller, David J. Steger, Mitchell A. Lazar*. Isoform-specific functions of PPARg in gene regulation and metabolism. Genes & Development, 2022 Mar 1;36(5-6):300-312.
3. Wenxiang Hu#*, Chunjie Jiang#, Mindy Kim, Wenjian Yang, Kun Zhu, Dongyin Guan, Wenjian Lv, Yang Xiao, Jessica R Wilson, Daniel J Rader, Ching-Hon Pui, Mary V. Relling, Mitchell A. Lazar*. Individual-specific functional epigenomics reveals genetic determinants of adverse metabolic effects of glucocorticoids. Cell Metabolism, 2021.(Highlighted by Nature Review Endocrinology)
4. Wenxiang Hu#, Chunjie Jiang#, Dongyin Guan, Pieterjan Dierickx, Rong Zhang, Arden Moscati, Girish N. Nadkarni, David J. Steger, Ruth J.F. Loos, Cheng Hu, Weiping Jia, Raymond E. Soccio, and Mitchell A. Lazar*. Patient adipose stem cell-derived adipocytes reveal genetic variation that predicts anti-diabetic drug response. Cell Stem Cell, 2019 Feb 7;24(2):299-308 (Cover story, Preview by Cell Stem Cell, Highlighted by Nature medicine and Nature Review Endocrinology)
5. Wenxiang Hu#, Binlong Qiu#, Wuqiang Guan#, Qinying Wang, Min Wang, Wei Li, Longfei Gao, Lu Shen, Yin Huang, Gangcai Xie, Hanzhi Zhao, Ying Jin, Beisha Tang, Yongchun Yu, Jian Zhao*, and Gang Pei*. Direct Conversion of Normal and Alzheimer’s Disease Human Fibroblasts into Neuronal Cells by Small Molecules. Cell Stem Cell. 2015 Aug 6;17(2):204-12. ( Preview by Cell Stem Cell, Highlighted by Nature methods, Recommended by F1000)
6. Lin Cheng#, Wenxiang Hu#, Binlong Qiu#, Jian Zhao#*, Yongchun Yu, Wuqiang Guan, Min Wang, Wuzhou Yang and Gang Pei*. Generation of neural progenitor cells by chemical cocktails and hypoxia. Cell Research. 2014 doi: 10.1038/cr.2014.32.
7. Wenxiang Hu, Jian Zhao* and Gang Pei*. Activation of Aryl Hydrocarbon Receptor (AhR) by Tranilast, an Anti-allergy Drug, Promotes miR-302 Expression and Cell Reprogramming. J Biol Chem. 2013 Aug 9; 288(32):22972-84.
8. Dongyin Guan, Ying Xiong, Trang Minh Trinh, Yang Xiao, Wenxiang Hu, Chunjie Jiang, Pieterjan Dierickx, Cholsoon Jang, Joshua D.Rabinowitz, Mitchell A. Lazar*. The Hepatocyte Clock and Feeding Interdependently Control Chrono-Homeostasis of Multiple Liver Cell Types. Science. 2020 369 (6509), 1388-1394.
9. Kiara K Benson, Wenxiang Hu, Angela H Weller, Alexis H Bennett, Eric R Chen, Sumeet A Khetarpal, Satoshi Yoshino, William P Bone, Lin Wang, Joshua D Rabinowitz, Benjamin F Voight, Raymond E Soccio*. Natural human genetic variation determines basal and inducible expression of PM20D1, an obesity-associated gene. PNAS. 2019 116 (46), 23232-23242.
10. Yang Xiao, Kirill Batmanov, Wenxiang Hu, Kun Zhu, Alexander Y. Tom, Dongyin Guan, Chunjie Jiang, Lan Cheng, Sam J. McCright, Eric C. Yang, Matthew R. Lanza, Yifan Liu, David A. Hill, Mitchell A. Lazar*. Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis[J]. Science translational medicine. 2023, 15(682): eadc9653.