范小英研究员
教育经历
2008.08-2012.06，浙江大学，植物保护，本科
2012.09-2017.07，北京大学，细胞生物学，博士
工作经历
2017.07-2019.12，北京大学，博士后
2019.12-2021.04，生物岛实验室，研究员
2021.05至今，广州实验室，研究员
研究简介
课题组研究方向集中在两个方面：1. 单细胞测序技术开发：在过去的研究中建立了多种基于第二代高通量测序（NGS）和第三代单分子测序（TGS）平台的单细胞组学测序技术，逐步突破了单细胞测序在转录组、基因组方面检测能力的缺陷，并通过这些技术阐释了发育和疾病过程的细胞及分子特征。2.呼吸疾病的单细胞组学研究：围绕慢性阻塞性肺疾病、肺癌等呼吸系统疾病展开单细胞多组学研究，阐明疾病发生发展机制，寻找新的诊疗靶标。
人才头衔与荣誉奖励
1. 广州市黄埔区精英人才
2. 广东省重大人才项目青年拔尖人才
3. 2021年度中国生物信息学十大进展
代表性成果
1. Chang Lei#; Deng Enze#; Wang Jun#; Zhou Wei#; Ao Jian, Liu Rong, Su Dan; Fan Xiaoying*; Single-cell third-generation sequencing-based multi-omics uncovers gene expression changes governed by ecDNA and structural variants in cancer cells, Clinical and Translational Medicine 2023,13(8): e1351.
2. Fan Xiaoying#; Lu Ping#; Wang Hongwei#; Bian Shuhui#; Wu Xinglong#; Zhang Yu ; LiuYang; Fu Danqi; Wen Lu; Hao Jihui*; Tang Fuchou*; Integrated single-cell multiomics analysis reveals novel candidate markers for prognosis in human pancreatic ductal adenocarcinoma，Cell Discovery. 2022 Feb 15;8(1):13.
3. Fan Xiaoying#; Yang Cheng#; Li Wen#; Bai Xiuzhen; Zhou Xin; Xie Haoling; Wen Lu; Tang Fuchou*; SMOOTH-seq: single-cell genome sequencing of human cells on a third-generation sequencing platform.Genome Biology,2021 Jun;22(1):195.
4. Ren Xianwen#; Wen Wen#; Fan Xiaoying#; Hou Wenhong#; Su Bin#; Cai Pengfei#; Li Jiesheng#; Yang Liu#; Tang Fei#; Zhang Fan Zhang#; Yang Yu#; He Jiangping#; Ma Wenji#; He Jingjing#; Wang Pingping#; Cao Qiqi; Chen Fangjin; Chen Yuqing; Cheng Xuelian; Deng Guohong; Deng Xilong; Ding Wenyu; Feng Yingmei; Gan Rui; Guo Chuang; Guo Weiqiang; He Shuai; Jiang Chen; Liang Juanran; Li Yimin; Lin Jun; Ling Yun; Liu Haofei; Liu Jianwei; Liu Nianping; Liu Shuqiang; Luo Meng ; Ma Qiang; Song Qibing; Sun Wujianan; Wang Gaoxiang; Wang Feng; Wang Ying; Wen Xiaofeng; Wu Qian; Xu Gang; Xie Xiaowei; Xiong Xinxin; Xing Xudong; Xu Hao; Yin Chonghai; Yu Dongdong; Yu Kezhuo; Yuan Jin; Zhang Biao; Zhang Peipei; Zhang Tong; Zhao Jincun; Zhao Peidong; Zhou Jianfeng; Zhou Wei; Zhong Sujuan; Zhong Xiaosong; Zhang Shuye; Zhu Lin; Zhu Ping ; Zou Bin; Zou Jiahua; Zou Zengtao; BaiFan Bai; Huang Xi; Zhou Penghui*; Jiang Qinghua*; Hunag Zhiwei*; Bei Jinxin*; Wei Lai*; Bian Xiuwu*; Liu Xindong*; Cheng Tao*; Li Xiangpan*; Zhao Pingsen*; Wang Fusheng*; Wang Hongyang*; Su Bing*; Zhang Zheng*; Qu Kun*; Wang Xiaoqun*; Chen Jiekai*; Jin Ronghua*; Zhang Zemin*; COVID-19 immune features revealed by a large-scale single cell transcriptome atlas.Cell,2021 Nov;84(23):5838.
5. Fan Xiaoying#; Fu Yuanyuan#; Zhou Xin#; Sun Le#; Yang Ming; Wang Mengdi; Chen Ruiguo; Wu Qian; Yong Jun; Dong Ji; Wen Lu; Qiao Jie *; Wang Xiaoqun*; Tang Fuchou*; Single-cell transcriptome analysis reveals cell lineage specification in temporal-spatial patterns in human cortical development , Science Advances, 2020, 6(34): 0-eaaz2978.
6. Fan Xiaoying#; Tang Dong#; Liao Yuhan#; Li Pidong#; Zhang Yu; Wang Minxia; Liang Fan; Wang Xiao; Gao Yun; Wen Lu; Wang Depeng; Wang Yang*; Tang Fuchou*; Single-cell RNA-seq analysis of mouse preimplantation embryos by third generation sequencing, Plos Biology, 2020, 18(12).
7. Zhong Suijuan#; Zhang Shu#; Fan Xiaoying#; Wu Qian#; Yan Liying#; Dong Ji; Zhang Haofeng; Li Long; Sun Le; Pan Na; Xu Xiaohui; Tang Fuchou*; Zhang Jun*; Qiao Jie*; Wang Xiaoqun*; A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex , Nature, 2018, 555(7697): 524-+.
8. Fan Xiaoying#; Dong Ji#; Zhong Suijuan#; Wei Yuan#; Wu Qian; Yan Liying; Yong Jun; Sun Le; Wang Xiaoye; Zhao Yangyu; Wang Wei; Yan Jie; Wang Xiaoqun*; Qiao Jie*; Tang Fuchou*; Spatial transcriptomic survey of human embryonic cerebral cortex by single-cell RNA-seq analysis , Cell Research, 2018, 28(7): 730-745.
9. Liu Yawei#; Fan Xiaoying#; Wang Rui#; Lu Xiaoyin#; Dang Yan Li; Wang Huiying; Lin Hai Yan; Zhu Cheng; Ge Hao; Cross James C* ; Wang Hongmei* ; Single cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta , Cell Research, 2018, 28(8): 819-832.
10. Dong Ji#; Hu Yuqiong#; Fan Xiaoying#; Wu Xinglong#; Mao Yunuo; Hu Boqiang; Guo Hongshan; Wen Lu; Tang Fuchou*; Single-cell RNA-seq analysis unveils a prevalent epithelial/mesenchymal hybrid state during mouse organogenesis , Genome Biology, 2018, 19(1): 0-31.