研究简介
长期从事呼吸系统和中枢神经系统冠状病毒感染的致病机制、免疫调节机制，以及预防和治疗方法的研究。包括人类新突发病毒感染小鼠模型的快速建立；利用动物模型和人类样本系统研究SARS、MERS、COVID-19、流感等病毒感染后外周和肺脏局部的病毒特异性细胞和体液免疫应答规律，阐明保护性和致病性作用机制；根据病毒特异性T细胞应答水平，揭示中东和非洲地区MERS传播状况；发现并阐明冠状病毒特异性调节性T 细胞在体内的作用机制；开发冠状病毒广谱疫苗、治疗性抗体等。研究内容系统且连续，以第一/通讯作者（含共同）在主流期刊发表SCI论文22 篇，申请专利4项，获批1项。先后主持国家级项目4项、省部级项目2项，并长期保持良好的国际和粤港澳科研合作。
荣誉奖励
1. 2022中华医学科技奖，医学科学技术奖，三等奖，排名第四
代表性成果
1. Sun J#, Zhuang Z#, Zheng J#, Li K#, Wong RL#, Liu D#, Huang J#, He J#, Zhu A#, Zhao J#, Li X#, Xi Y#, Chen R, Alshukairi AN, Chen Z, Zhang Z, Chen C, Huang X, Li F, Lai X, Chen D, Wen L, Zhuo J, Zhang Y, Wang Y, Huang S, Dai J, Shi Y, Zheng K, Leidinger MR, Chen J, Li Y, Zhong N, Meyerholz DK, McCray PB Jr*, Perlman S*, Zhao J*. 2020.Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment. Cell. 182(3):734-743.e5.
2. Mok CKP#, Zhu A#, Zhao J#, Wang J, Chen Z, Zhuang Z, Wang Y, …Peiris M*, Zhao J*. 2020. T cell responses to MERS coronavirus infection in people with occupational exposure to dromedary camels in Nigeria: An observational cohort study. Lancet Infect Dis. S1473-3099(20)30599-5.
3. Wang Y#, Zhang L#, Sang L#, Ye F#, Ruan S#, Zhong B#, Song T#, Alshukairi AN#, Chen R#, Zhang Z, Gan M, Zhu A, Huang Y, Luo L, Mok CK, Al Gethamy MM, Tan H, Li Z, Huang X, Li F, Sun J, Zhang Y, Wen L, Li Y, Chen Z, Zhuang Z, Zhuo J, Chen C, Kuang L, Wang J, Lv H, Jiang Y, Li M, Lin Y, Deng Y, Tang L, Liang J, Huang J, Perlman S, Zhong N, Zhao J*, Malik Peiris JS*, Li Y*, Zhao J*. 2020. Kinetics of viral load and antibody response in relation to COVID-19 severity. J Clin Invest.130(10):5235-5244.
4. Zhuang Z#, Lai X#, Sun J#, Chen Z#, Zhang Z#, Dai J#, Liu D#, Li Y#, Li F#, Wang Y, Zhu A, Wang J, Yang W, Huang J, Li X, Hu L, Wen L, Zhuo J, Zhang Y, Chen D, Li S, Huang S, Shi Y, Zheng K, Zhong N, Zhao J*, Zhou D*, Zhao J*. 2021. Mapping and role of T cell response in SARS-CoV-2-infected mice. J Exp Med.218(4):e20202187.
5. Wang Y#, Wang D#, Zhang L#, Sun W#, Zhang Z#, Chen W#, Zhu A#, Huang Y#, Xiao F, Yao J, Gan M, Li F, Luo L, Huang X, Zhang Y, Wong SS, Cheng X, Ji J, Ou Z, Xiao M, Li M, Li J, Ren P, Deng Z, Zhong H, Xu X, Song T, Mok CKP, Peiris M, Zhong N, Zhao J*, Li Y*, Li J*, Zhao J*. 2021. Intra-host variation and evolutionary dynamics of SARS-CoV-2 populations in COVID-19 patients. Genome Med.13(1):30.
6. Zhang Z#, Zeng E#, Zhang L#, Wang W#, Jin Y#, Sun J#, Huang S#, Yin W#, Dai J, Zhuang Z, Chen Z, Sun J, Zhu A, Li F, Cao W, Li X, Shi Y, Gan M, Zhang S, Wei P, Huang J, Zhong N, Zhong G*, Zhao J*, Wang Y*, Shao W*, Zhao J*. 2021.Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivo. Cell Discov.7(1):65.
7. Liu D#, Chen C#, Chen D#, Zhu A#, Li F#, Zhuang Z, Mok CKP#, Dai J#, Li X#, Jin Y#, Chen Z, Sun J, Wang Y, Li Y, Zhang Y, Wen L, Zhang Z, Zhuo J, Wang J, Ran W, Wang D, Zhang S, Tang Y, Li S, Lai X, Wei P, Yuan J, Chen F, Huang S, Sun F, Qian Z, Tan W, Zhao J*, Peiris M*, Zhao J*. 2023. Mouse models susceptible to HCoV-229E and HCoV-NL63 and cross protection from challenge with SARS-CoV-2. Proc Natl Acad Sci U S A. 120(4):e2202820120. doi: 10.1073/pnas.2202820120
8. Zhao J#, Alshukairi AN#, Baharoon SA, Ahmed WA, Bokhari AA, Nehdi AM, Layqah LA, Alghamdi MG, Al Gethamy MM, Dada AM, Khalid I, Boujelal M, Al Johani SM, Vogel L, Subbarao K, Mangalam A, Wu C, Ten Eyck P*, Perlman S*, Zhao J*. 2017. Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses. Sci Immunol. 2(14). pii: eaan5393
9. Zhao, J#*., J. Zhao#, A.K. Mangalam, R. Channappanavar, C. Fett, D.K. Meyerholz, S. Agnihothram, R. Baric, C.S. David, S. Perlman*. 2016. Airway Memory CD4 T Cells Mediate Protective Immunity against Emerging Human Respiratory Coronaviruses. Immunity, 44(6):1379-91
10. Zhao, J., J. Zhao, C. Fett, K. Trandem, E. Fleming, and S. Perlman*. 2011. IFN-gamma- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis. J Exp Med 208: 1571-1577.
