崔桂忠研究员
教育经历
2010/09-2014/07，西北农林科技大学，生物技术，学士
2014/09-2019/06，中国科学院大学上海生物化学与细胞生物学研究所，发育生物学，博士
工作经历
2019/09-2022/07，生物岛实验室，副研究员
2022/07至今，广州实验室，研究员
2022/10至今，广州医科大学，教授
研究简介
本课题组的主要研究方向是发展和利用单细胞和空间多组学技术，研究呼吸系统器官发育及肺癌发生过程中细胞命运的时空转录调控机制。细胞生命活动是一个高维、动态、有序的生物学过程，细胞命运受到精细的时、空调控。胚胎发育是一个高度程式化的系统，而肿瘤发生与器官发育共享诸多调控网络。研究团队前期建立了Geo-seq、Auto-seq等单细胞空间组学技术平台，结合基因编辑、遗传示踪等技术揭示了胚层细胞命运建立过程的分子调控机制、物种特异性转录调控网络和干细胞在损伤再生过程中的多种分化潜能等。共发表论文26篇，他引800余次，其中在包括Nature、Nature Genetics、Cell Reports等杂志发表第一/通讯（含共同）作者论文十余篇，相关研究成果曾获得“中国生命科学十大进展”等。
人才头衔与荣誉奖励
1. 2020年获得广州开发区“精英人才”称号；
2. 2020年获得上海市细胞生物学学会“优秀青年学者”称号；
代表性成果
1.Fangfang Qu#; Wenjia Li#; Jian Xu#; Ruifang Zhang; Jincan Ke; Xiaodie Ren; Xiaogao Meng; Lexin Qin; Jingna Zhang; Fangru Lu; Xin Zhou; Xi Luo; Zhen Zhang; Minhan Wang; Guangming Wu; Duanqing Pei; Jiekai Chen; Guizhong Cui*; Shengbao Suo*; Guangdun Peng*; Three-dimensional molecular architecture of mouse organogenesis, Nature Communications, 2023, 14(1): 4599
2.Shai Ovadia#, Guizhong Cui#, Ran Elkon, Mazal Cohen-Gulkar, Nitay Zuk-Bar, Tran Tuoc, Naihe Jing*, Ruth Ashery-Padan*. SWI/SNF complexes are required for retinal pigmented epithelium differentiation and for the inhibition of cell proliferation and neural differentiation programs. Development, 2023, 150(16).
3.Xiaogao Meng, Guizhong Cui*, Guangdun Peng*. Lung development and regeneration: newly defined cell types and progenitor status. Cell Regeneration, 2023, 12(1): 5.
4.Guizhong Cui#, Su Feng#, Yaping Yan#, Li Wang, Xiechao He, Xi Li, Yanchao Duan, Jun Chen, Patrick P.L. Tam, Ke Tang, Ping Zheng, Wei Si*, Naihe Jing*, Guangdun Peng*. Spatial molecular anatomy of germ layers in the gastrulating Cynomolgus monkey embryo. Cell Reports, 2022, 40(9): 111285-111285.
5.Qing Xia#, Guizhong Cui#, Ye Fan#, Xiuqin Wang, Gongcheng Hu, Lisha Wang, Xi Luo, Lele Yang, Qingqing Cai, Kaibiao Xu, Wenjing Guo, Minghui Gao, Yingying Li, Ji Wu, Wei Li, Jiayu Chen, Huayu Qi, Guangdun Peng*, Hongjie Yao*. RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes. Cell Proliferation, 2021, 54(5): e13000.
6.Di Demi He#, Xinyu Thomas Tang#, Wenjie Dong#, Guizhong Cui#, Guangdun Peng, Xiujuan Yin, Yujie Chen, Naihe Jing, Bo O. Zhou*. C-KIT Expression Distinguishes Fetal from Postnatal Skeletal Progenitors. Stem Cell Reports, 2020, 14(4): 614-30.
7.Guangdun Peng#*, Shengbao Suo#, Guizhong Cui#, Fang Yu#, Ran Wang, Jun Chen, Shirui Chen, Zhiwen Liu, Guoyu Chen, Yun Qian, Patrick P. L. Tam, Jing-Dong J. Han*, Naihe Jing*. Molecular architecture of lineage allocation and tissue organization in early mouse embry. Nature, 2019, 572(7770): 528-32.
8.Qiaozhen Liu#, Kuo Liu#, Guizhong Cui#, Xiuzhen Huang, Shun Yao, Wenke Guo, Zhen Qin, Yan Li, Rui Yang, Wenjuan Pu, Libo Zhang, Lingjuan He, Huan Zhao, Wei Yu, Muxue Tang, Xueying Tian, Dongqing Cai, Yu Nie, Shengshou Hu, Tao Ren, Zengyong Qiao, Hefeng Huang, Yi Arial Zeng, Naihe Jing, Guangdun Peng*, Hongbin Ji*, Bin Zhou*. Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nature Genetics, 2019, 51(4): 728-38.
9.Guizhong Cui#, Shengbao Suo#, Ran Wang, Yun Qian, Jing-Dong J. Han*, Guangdun Peng*, Patrick P. L. Tam*, Naihe Jing*. Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning. Development, Growth & Differentiation, 2018, 60(8): 463-72.