曹尚涛研究员
教育经历
2008.09-2013.06，南方医科大学，基础医学，本科
2013.09-2018.06，中国科学院广州生物医药与健康研究院，细胞生物学，博士
工作经历
2018.07-2019.11，中国科学院广州生物医药与健康研究院，助理研究员
2019.12-2022.06，生物岛实验室，副研究员
2022.07至今，广州实验室，研究员
2022.10至今，广州医科大学，特聘教授（兼职）
研究简介
课题组主要围绕干细胞命运调控与发育细胞谱系解析展开研究。结合化学小分子与类器官培养，通过体细胞重编程，多能干细胞定向分化和原代分离培养等技术，开发新型的人类器官模型模拟研究发育调控机制与致病机理，以及建立功能干细胞体外诱导维持扩增技术体系与稳态调控机制研究。重点探索呼吸系统肺与鼻发育细胞谱系演变规律与上皮干细胞再生应用。主要研究方向如下：
1. 呼吸系统肺、鼻发育时空谱系解析与体外再造；
2. 肺、鼻上皮细胞命运决定与再生治疗；
3. 化学小分子诱导调控细胞命运转化；
人才头衔与荣誉奖励
1. 2019年入选广州市黄埔区高层次精英人才
2. 2018年荣获中国科学院院长奖优秀奖
代表性成果
1. Cao, S# *., Feng, H#., Yi, H#., Pan, M#., Lin, L#., Zhang, Y. S#., Feng, Z#., Liang, W., Cai, B., Li, Q., Xiong, Z., Shen, Q., Ke, M., Zhao, X., Chen, H., He, Q., Min, M., Cai, Q., Liu, H., Wang, J., Pei, D.*, Chen, J.*, and Ma, Y. * Single-cell RNA sequencing reveals the developmental program underlying proximal-distal patterning of the human lung at the embryonic stage. Cell Research 1-13 (2023)
2. Cao, S.#, Yu, S.#, Li, D.#, Ye, J., Yang, X., Li, C., Wang, X., Mai, Y., Qin, Y., Wu, J., He, J., Zhou, C., Liu, H., Zhao, B., Shu, X., Wu, C., Chen, R., Chan, W., Pan, G., Chen, J., Liu, J. *, and Pei, D.* Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency. Cell Stem Cell 22, 529-542 e525(2018)
3. Yu, S#.., Zhou, C.#., Cao, S.#., He, J.#., Cai, B., Wu, K., Qin, Y., Huang, X., Xiao, L., Ye, J., Xu, S., Xie, W., Kuang, J., Chu, S., Guo, J., Liu, H., Pang, W., Guo,L., Zeng, M., Wang, X., Luo, R., Li, C., Zhao, G., Wang, B., Wu, L., Chen, J., Liu, J.*, and Pei, D.* BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling. Nature Cell Biology 22, 651-662 (2020)
4. Yu, S.#, Zhou, C.#, He, J.#, Yao, Z., Huang, X., Rong, B., Zhu, H., Wang, S., Chen, S., Wang, X., Cai, B., Zhao, G., Chen, Y., Xiao, L., Liu, H., Qin, Y., Guo, J., Wu, H., Zhang, Z., Zhang, M., Zhao, X., Lan, F., Wang, Y., Chen, J., Cao, S*., Pei, D*. and Liu, J*. BMP4 drives primed to naïve transition through PGC-like state. Nature communications 22, 651-662 (2022)
5. Qin, Y.#, Huang, X. #, Cai, Z., Cai, B., He, J., Yao, Y., Zhou, C., Kuang, J., Yang, Y., Chen, H., Chen, Y., Ou, S., Chen, L., Wu, F., Guo, N., Yuan, Y., Zhang, X., Pang, W., Feng, Z., Yu, S., Liu, J., Cao, S*., and Pei, D*. Regeneration of Human Segmentation Clock by Reprogramming. EMBO Journal (2022)
6. Yuan, Y.#.., Chen, H.#., Ou, S., Cai, B., Zhang, R., Qin, Y., Pan, M., Cao, S.*, Pei, D. *, and Hou, F. F. * Generation of mitochondria-rich kidney organoids from expandable intermediate mesoderm progenitors reprogrammed from human urine cells under defined medium. Cell & Bioscience (2022)
7. Zhang, X.#, Chen, L.#., Huang, X.#., Chen, H., Cai, B., Qin, Y., Chen, Y., Ou, S., Li, X., Wu, Z., Feng, Z., Zeng, M., Guo, W., Li, H., Zhou, C., Yu, S., Pan, M., Liu, J., Kang, K*., Cao, S*., and Pei, D*. MYOCD is Required for Cardiomyocyte-like Cells Induction from Human Urine Cells and Fibroblasts Through Remodeling Chromatin. Stem Cell Reviews and Reports (2022)
8. Cao, S., Yu, S., Chen, Y., Wang, X., Zhou, C., Liu, Y., Kuang, J., Liu, H., Li, D., Ye, J., Qin, Y., Chu, S., Wu, L., Guo, L., Li, Y., Shu, X., Chen, J., Liu, J.*, and Pei, D. * Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage. Journal of Biological Chemistry 292, 19122-19132(2017)
9. Zhang, X. #, Zhang, Q. #, Chen, L. #, Cai, B., Zeng, M., Ou, S., Chen, Y., Feng, Z., Chen, H., Cao, S.*, and Kang, K.* Appropriate Exogenous Expression Stoichiometry of GATA4 as an Important Factor for Cardiac Reprogramming of Human Dermal Fibroblasts. Cellular Reprogramming (2022)
10. Fu, M.#., Chen, H.#., Cai, Z.#, Yang, Y., Feng, Z., Zeng, M., Chen, L., Qin, Y., Cai, B., Zhu, P., Zhou, C., Yu, S., Guo, J., Liu, J*., Cao, S*., and Pei, D*. Forkhead box family transcription factors as versatile regulators for cellular reprogramming to pluripotency. Cell Regeneration 10, 17 (2021)