曾永昇研究员
教育经历
2004-2008，新加坡国立大学，生命科学，本科
2008-2013，新加坡国立大学，生命科学，博士
工作经历
2012-2016，新加坡基因组研究所 A*STAR，博士后
2016-2021，新加坡基因组研究所 A*STAR，初级研究员
2021，生物岛实验室，研究员
2022至今，广州实验室，研究员
研究简介
成体干/祖细胞在补充缺失的体细胞和疾病发生发展过程中均扮演了重要角色。我们实验室关注于成体干/祖细胞是如何能够获得疾病“记忆”（基因与表观遗传）以及在促进疾病复发再发和早期癌症起始过程中的作用。主要科学问题包括：1）成体干/祖细胞如何促进疾病的表现，2）成体干/祖细胞细胞如何积累并促进疾病易感性和复发性的疾病记忆。为了深入了解这些科学问题，我们实验室从成体组织中分离获得了可以自我更新的原代细胞，并利用不同培养系统构建疾病模型，如慢性阻塞性肺疾病和肺癌。同时，我们实验室也致力于开发诱导成体组织再生的创新性治疗策略（工程化外泌体），重新活化并扩大成体组织中干细胞群体以及重塑影响组织再生的微环境。
人才头衔与荣誉奖励
1. Gilead肝病科研学者（亚洲）
代表性成果
1. Yue Liu, Jian-Ying Sheng, Chun-Fang Yang, Junjun Ding, Yun-Shen Chan*. 2023. A decade of liver organoids: Advancements in disease modeling. Clinical and Molecular Hepatology. 29(3):643.
2. Neslihan A Kaya, Jianbin Chen, Hannah Lai, Hechuan Yang, Liang Ma, Xiaodong Liu, Jacob Santiago Alvarez, Jin Liu, Axel M Hillmer, David Tai, Joe Yeong Poh Sheng, Zheng Hu, Yun Shen Chan, Pierce K H Chow, Yuguang Mu, Torsten Wuestefeld, Weiwei Zhai*. 2022. Genome instability is associated with ethnic differences between Asians and Europeans in hepatocellular carcinoma. Theranostics. 12(10):4703.
3.Zhipeng Ai, Xinyu Xiang,Yangquan Xiang, Iwona Szczerbinska, Yuli Qian, Xiao Xu, Chenyang Ma, Yaqi Su, Bing Gao, Hao Shen, Muhammad Nadzim Bin Ramli, Di Chen, Yue Liu, Jia-jie Hao, Huck Hui Ng, Dan Zhang*, Yun-Shen Chan*,Wanlu Liu*, Hongqing Liang*. 2022. Kruppel-like factor 5 rewires NANOG regulatory network to activate human naive pluripotency spe-cific LTR7Ys and promote naive pluripotency. Cell Reports. 40: 111240.
4. Shi-Xiang Wang, Ji-Song Yan,Yun-Shen Chan*. 2022. Advancements in MAFLD Modeling with Human Cell and Organoid Models. International journal of molecular sciences. 23(19):11850.
5. Do Thuy Uyen Ha Lam, Yock Young Dan, Yun-Shen Chan* ,Huck-Hui Ng. 2021. Emerging liver organoid platforms and technologies. Cell Regeneration. 10(1):27.
6. Muhammad Nadzim Bin Ramli, Yee Siang Lim, Chwee Tat Koe, Deniz Demircioglu,Weiquan Tng, Kevin Andrew Uy Gonzales,Cheng Peow Tan, Iwona Szczerbinska,Hongqing Liang, Einsi Lynn Soe, Zhiping Lu,Chaiyaboot Ariyachet, Ka Man Yu,Shu Hui Koh, Lai Ping Yaw, Nur Halisah Binte Jumat, John Soon Yew Lim,Graham Wright, Asim Shabbir, Yock Young Dan, Huck-Hui Ng,Yun-Shen Chan*. 2020. Human Pluripotent Stem Cell-Derived Organoids as Models of Liver Disease. Gastroenterology. 159(4): 1471.Ariyachet, Ka Man Yu,Shu Hui Koh, Lai Ping Yaw, Nur Halisah Binte Jumat, John Soon Yew Lim,Graham Wright, Asim Shabbir, Yock Young Dan, Huck-Hui Ng,Yun-Shen Chan*. 2020. Human Pluripotent Stem Cell-Derived Organoids as Models of Liver Disease. Gastroenterology. 159(4): 1471.
7. Iwona Szczerbinska, Kevin Andrew Uy Gonzales, Engin Cukuroglu,Muhammad Nadzim Bin Ramli, Bertha Pei Ge Lee, Cheng Peow Tan, Cheng Kit Wong,Giulia Irene Rancati, Hongqing Liang, Jonathan Goke, Huck-Hui Ng*, Yun-Shen Chan*. 2019. A Chemically Defined Feeder-free System for the Establishment and Maintenance of the Human Naive Pluripotent State. Stem Cell Reports. 13(4): 612.
8.Chan YS, Göke J, Lu X, Venkatesan N, Feng B, Su IH, Ng HH. A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming. Stem Cells 2013; 4, 682-92.
9. Yun-Shen Chan* ,Jonathan Goke, Jia-Hui Ng, Xinyi Lu, Kevin Andrew Uy Gonzales, Cheng-Peow Tan,Wei-Quan Tng, Zhong-Zhi Hong, Yee-Siang Lim, Huck-Hui Ng*. 2013. Induction of a Human Pluripotent State with Distinct Regulatory Circuitry that Resembles Preimplantation Epiblast. Cell Stem Cell. 13(6): 663.
10. Na-Yu Chia*, Yun-Shen Chan*, Bo Feng*, Xinyi Lu, Yuriy L.Orlov, Dimitri Moreau, Pankaj Kumar, Lin Yang,Jianming Jiang, Mei-Sheng Lau, Mikael Huss, Boon-Seng Soh, Petra Kraus, Pin Li, Thomas Lufkin, Bing Lim,Nei D. Clarke, Frederic Bard*, Huck-Hui Ng*. 2010. A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature. 468(7321): 316.