José Silva研究员
教育经历
1992.10-1997.09，波尔图大学，生物学，本科
1997.10-1998.09，波尔图大学，生物学，硕士
1998.10-2003.03，波尔图大学/帝国理工学院，生物医学科学，博士
工作经历
2003.04-2006.09，爱丁堡大学，博士后研究员
2006.10-2008.05，剑桥大学，博士后研究员
2008.06-2020.10，剑桥大学，研究员
2020.11-2021.04，生物岛实验室，研究员
2021.05至今，广州实验室，研究员
研究简介
José Carlos Rebelo da Silva博士，广州实验室研究员，国家重大人才项目入选者。来华前，曾在剑桥大学Wellcome-MRC干细胞研究所担任首席研究员长达12年，曾先后获得过极具竞争力的Wellcome Trust Advanced Research Fellowship Award 和Wellcome Trust Senior Research Fellowship Award。主要从事细胞命运决定与干细胞相关研究，是干细胞和重编程研究领域的开创者和领军人物。目前的研究重点是开发新型的、可模拟胚胎发育的小鼠和人的胚胎模型，旨在体外获得高质量的功能性细胞，应用于再生医学。Silva博士以通讯作者的身份在顶级科学杂志Cell、Nature、Nature Cell Biology、Nature Communications、Developmental Cell和Cell Stem Cell等发表多篇论文，目前已授权高质量专利3篇，正在申请中专利3篇。
人才头衔与荣誉奖励
1. 国家重大人才项目入选者
2. 广东省高层次人才创新团队负责人
代表性成果
1.Mingyue Guo*, Jinyi Wu, Chuanxin Chen, Xinggu Wang, An Gong, Wei Guan, Rowan M. Karvas, Kexin Wang, Mingwei Min, Yixuan Wang, Thorold W.Theunissen, Shaorong Gao, Jose C. R. Silva*. 2023. Self-renewing human naïve pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously. Nature Communications (Accepted).
2.Huanhuan Li*, Litao Chang, Jinyi Wu, Jiahui Huang, Wei Guan, Lawrence E. Bates, Hannah T. Stuart, Mingyue Guo, Pengfei Zhang, Boyan Huang, Chuanxin Chen, Man Zhang, Jiekai Chen, Mingwei Min, Guangming Wu, Andrew P. Hutchins, and Jose´ C.R. Silva*. 2023. In vitro generation of mouse morula-like cells. Developmental Cell. 58, 1-18.
3.Labouesse C, Tan B, Agley C, Moritz H, Winkel A, Stirparo GG, Stuart H, Verstreken C, Mulas C, Mansfield W, Bertone P, Franze K, Silva JCR*, Chalut K*. 2021. StemBond hydrogels control the mechanical microenvironment for pluripotent stem cells. Nature Communications. 12(1):6132.
4.Hannah T. Stuart, Giuliano G. Stirparo, Tim Lohoff, Lawrence E. Bates, Masaki Kinoshita, Chee Y. Lim, Elsa J. Sousa, Katsiaryna Maskalenka, Aliaksandra Radzisheuskaya, Andrew A. Malcolm, Mariana R.P. Alves, Rebecca L. Lloyd, Sonia Nestorowa, Peter Humphreys, William Mansfield, Wolf Reik, Paul Bertone,Jennifer Nichols, Berthold Gottgens, and Jose´ C.R. Silva*. 2019. Distinct Molecular Trajectories Converge to Induce Naive Pluripotency. Cell stem cell. 25, 388-406.
5.Elsa J. Sousa, Hannah T. Stuart, Lawrence E. Bates, Mohammadmersad Ghorbani, Jennifer Nichols, Sabine Dietmann, and Jose´ C.R. Silva*. 2018. Exit from Naive Pluripotency Induces a Transient X Chromosome Inactivation-like State in Males. Cell stem cell. 22, 919–928.
6.Santos R, Tosti L, Radzisheuskaya A, Caballero I, Kaji K, Hendrich B, Silva JCR*. 2014. Mbd3/NuRD facilitates induced pluripotency in a context dependent manner. Cell Stem Cell. 15(1):102-10.
7.Yael Costa, Junjun Ding, Thorold W. Theunissen, Francesco Faiola, Timothy A. Hore, Pavel V. Shliaha, Miguel Fidalgo, Arven Saunders, Moyra Lawrence, Sabine Dietmann, Satyabrata Das, Dana N. Levasseur, Zhe Li, Mingjiang Xu, Wolf Reik, Jose´ C. R. Silva* & Jianlong Wang*. 2013. NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature. VOL495, 370-374.
8.Aliaksandra Radzisheuskaya, Gloryn Le Bin Chia, Rodrigo L. dos Santos, Thorold W. Theunissen, L. Filipe C. Castro, Jennifer Nichols and José C. R. Silva*. 2013. A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages. Nature cell biology. VOL15, 579-590.
9.Jose Silva*, Jennifer Nichols, Thorold W. Theunissen, Ge Guo, Anouk L. van Oosten, Ornella Barrandon, Jason Wray, Shinya Yamanaka, Ian Chambers, and Austin Smith*. 2009. Nanog is the Gateway to the Pluripotent Ground State. Cell. 138, 722–737.
10.Jose´ Silva, Ian Chambers, Steven Pollard & Austin Smith. 2006. Nanog promotes transfer of pluripotency after cell fusion. Nature. VOL441, 997-1001.