田鲁亦研究员
教育经历
2009.09-2013.07，浙江大学，生物信息，本科
2015.02-2016.12，墨尔本大学，生物信息，硕士
2017.04-2021.03，墨尔本大学，生物医学，博士
工作经历
2021.03-2022.11，美国博德研究所，博士后
2022.11至今，广州实验室，研究员
2023.09至今，广州医科大学，特聘教授（兼职）
2023.09至今，广州医科大学，特聘教授（兼职）
研究简介
田鲁亦，广州国家实验室研究员(PI)，广州医科大学特聘教授，国家重大人才项目入选者(青年)，墨尔本大学生物医学专业博士，之后在美国博德研究所（Broad Institute）从事研究工作。课题组干湿结合，主要从事单细胞组学，空间组学和纳米孔测序的新设备和新技术研发，以及相应的数据分析流程和新算法开发。课题组用新组学技术研究免疫系统在时间和空间上的调控以及在呼吸疾病中的作用。生物学方面研究成果包括造血干细胞分化谱系追踪，研究免疫系统癌症耐药性，建立新冠感染的免疫反应多组学时间动态图谱等。技术方面开发了单细胞全长转录组技术和对应的数据分析流程，以及空间转录组3D拼接算法。以第一或通讯作者在Nature Methods，Nature Immunology，Immunity（封面文章），Nature Genetics，Nature Biotechnology，Blood，STTT，Genome Biology等在内的专业杂志发表高水平论文，他引超过2000次、H-index为19。
人才头衔与荣誉奖励
国家重大人才项目入选者（青年）
代表性成果
1.Abhishek Sampath Kumar, Luyi Tian, Adriano Bolondi, Amèlia Aragonés Hernández, Robert Stickels, Helene Kretzmer, Evan Murray, Lars Wittler, Maria Walther, Gabriel Barakat, Leah Haut, Yechiel Elkabetz, Evan Z. Macosko, Léo Guignard, Fei Chen & Alexander Meissner. Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis. Nature Genetics. 2023 July;1061-4036，55(7):1176-1185.
2.Thijssen R, Tian L, Anderson MA, Flensburg C, Jarratt A, Garnham AL, Jabbari JS, Peng H, Lew TE, Teh CE, Gouil Q, Georgiou A, Tan T, Djajawi TM, Tam CS, Seymour JF, Blombery P, Gray DHD, Majewski IJ, Ritchie ME, Roberts AW, Huang DCS.Single-cell multiomics reveal the scale of multilayered adaptations enabling CLL relapse during venetoclax therapy. Blood.2022 NOV 17;0006-4971，140 (20): 2127–2141.
3.Tian L, Chen F, Macosko EZ. The expanding vistas of spatial transcriptomics. Nature Biotechnology . 2023 Jun;1087-0156，41(6):773-782.
4.Tian L, Jabbari JS, Thijssen R, Gouil Q, Amarasinghe SL, Voogd O, Kariyawasam H, Du MRM, Schuster J, Wang C, Su S, Dong X, Law CW, Lucattini A, Prawer YDJ, Collar-Fernández C, Chung JD, Naim T, Chan A, Ly CH, Lynch GS, Ryall JG, Anttila CJA, Peng H, Anderson MA, Flensburg C, Majewski I, Roberts AW, Huang DCS, Clark MB, Ritchie ME. Comprehensive characterization of single-cell full-length isoforms in human and mouse with long-read sequencing. Genome Biology. 1474-760X,2021 Nov 11;22(1):310.
5.Zhao XN, You Y, Cui XM, Gao HX, Wang GL, Zhang SB, Yao L, Duan LJ, Zhu KL, Wang YL, Li L, Lu JH, Wang HB, Fan JF, Zheng HW, Dai EH, Tian LY, Ma MJ. Single-cell immune profiling reveals distinct immune response in asymptomatic COVID-19 patients. Signal Transduct Target Ther.2095-9907, 2021 Sep 16;6(1):342.
6.Tian L, Tomei S, Schreuder J, Weber TS, Amann-Zalcenstein D, Lin DS, Tran J, Audiger C, Chu M, Jarratt A, Willson T, Hilton A, Pang ES, Patton T, Kelly M, Su S, Gouil Q, Diakumis P, Bahlo M, Sargeant T, Kats LM, Hodgkin PD, O'Keeffe M, Ng AP, Ritchie ME, Naik SH. Clonal multi-omics reveals Bcor as a negative regulator of emergency dendritic cell development. Immunity. 2021 Jun 8;1074-7613,54(6):1338-1351.
7.Amann-Zalcenstein D, Tian L, Schreuder J, Tomei S, Lin DS, Fairfax KA, Bolden JE, McKenzie MD, Jarratt A, Hilton A, Jackson JT, Di Rago L, McCormack MP, de Graaf CA, Stonehouse O, Taoudi S, Alexander WS, Nutt SL, Ritchie ME, Ng AP, Naik SH. A new lymphoid-primed progenitor marked by Dach1 downregulation identified with single cell multi-omics. Nature Immunolology. 2020 Dec;1529-2908,21(12):1574-1584.
8.Tian L, Dong X, Freytag S, Lê Cao KA, Su S, JalalAbadi A, Amann-Zalcenstein D, Weber TS, Seidi A, Jabbari JS, Naik SH, Ritchie ME. Benchmarking single cell RNA-sequencing analysis pipelines using mixture control experiments. Nat Methods. 2019 Jun; 1548-7091,16(6):479-487.